Endocrine Abstracts

Introduction: We present the case of a clinically functioning gonadotroph adenoma in a pre-menopausal woman with abdominal pain, bilateral multi-cystic ovaries and fibromatosis. To our knowledge, this is the first case of fibromatosis associated with a functioning gonadotroph adenoma.Case: A 36 year old female presented on three occasions with acute abdominal pain. She was previously well and had two normal pregnancies. On the first admission, she underw...

Background: The cortisol circadian rhythm has an early morning peak with an increase before awakening, and a second lunchtime peak. Using a UPLC-MS/MS technique to measure prednisolone, the active metabolite of prednisone, we investigated the suitability of modified release (MR) prednisone (Lodotra) as a replacement therapy.Method: Blood samples were taken at fixed time points after the administration of MR-prednisone. Concentrations of the active metabo...